Westmead Dermatology
Striving towards disease-free skin
Recently, Ali Azimi had the privilege to attend the 22nd International Mass Spectrometry Conference (IMSC2018), in Florence, Italy. “The IMSC is the largest international conference on mass spectrometry and allied topics with a history of more than fifty years. The venue of the conference which was held from 25-31 August 2018 was the historic “Fortezza …
We are pleased to announce that our paper investigating the suitability of non-invasively collected (tape-stripped) stratum corneum samples from the patients with actinic keratosis for downstream proteomic investigation has been published in the Journal of Proteomics Clinical Application. Our paper is one more step in the development of new diagnosis techniques for actinic keratosis using …
Instagram and Snapchat users have positive attitudes about tanning and more frequently tanned intentionally within the last year. Lisa Abbot and our team at Skin & Cancer Foundation Australia has studied the relationship between Social Media, Selfies and Tanning. Younger Australians and females feel more attractive when tanned and tanned intentionally in the last year. …
Westmead Dermatology is working to develop a better way to follow up patients with lymphomas of the skin. Cutaneous Lymphomas (CTCL, Mycosis Fungoides) are rare skin cancers with a variable clinical presentation including patches, plaques and nodules on the skin that mimics common diseases such as eczema and psoriasis. Cutaneous lymphomas are diagnosed and monitored …
Our basic research team at the Department of Dermatology has recently employed laser-capture microdissection (LCM) coupled with the high sensitive sequential window acquisition of all theoretical mass spectra (SWATH™-MS) proteomics workflow to conduct a comprehensive proteomic profiling of normal skin, actinic keratosis (AK), Bowen’s disease (BD), well differentiated cutaneous squamous cell carcinoma (WD-cSCC), moderately differentiated …
We are excited to publish our article entitled “Incidence of Basal Cell Carcinoma (BCC) and Squamous Cell Carcinomas (SCC) in Patients on Anti-Programmed Cell Death-1 Therapy (anti-PD1) for Metastatic Melanoma” in the Journal of Immunotherapy. BCCs and SCCs are the bread and butter of dermatology in Australia. This is the first study comparing the incidence …
We are delighted to have published our research article entitled “Differential Proteomic Analysis of Actinic Keratosis, Bowen’s Disease and Cutaneous Squamous Cell Carcinoma by Label-Free LC-MS/MS” in the Journal of Dermatological Science. In this paper, we report on proteomic investigations of formalin-fixed paraffin embedded (FFPE) actinic keratosis (AK), Bowen’s disease (BD), and cutaneous squamous cell …
Naevus lightening is a fascinating phenomenon found in patients on BRAF inhibitors and MEK inhibitors combination therapy (BiMiC) and checkpoint immunotherapy. We have recently published a study unravelling the mystery underlining this phenomenon. We biopsied 7 lightened naevi from metastatic melanoma patients on either BiMiC or checkpoint immunotherapy such as pembrolizumab. Under the microscope, we …
Sequential Windowed Acquisition of All Theoretical Fragment Ion Mass Spectra (SWATH) is one of the premier mass spectrometry acquisition strategies for identification and quantitation of proteins in a complex sample. Unlike other mass spectrometry strategies, SWATH technique allows comprehensive detection and quantitation of virtually every detectable analyte in a sample. Crossmatching these analytes with an …
During the last meeting of the Australasian Society for Dermatology Research, Pablo Fernandez-Peñas presented a review of the influence of cellular and biochemical pathways in understanding diseases. Pablo described how the use of BRAF inhibitors in melanoma created a number of cutaneous effects. Clinical findings and basic research (including original research by our group) helped …
