Non-invasive proteomic analysis of Mycosis Fungoides

We are pleased to share the news that our recent article entitled “Tape Stripped Stratum Corneum Samples are Suitable for Diagnosis and Comprehensive Proteomic Investigation in Mycosis Fungoides” has been accepted for publication at the journal of Proteomics Clinical Application – DOI:10.1002/prca.202200039.

This study, for the first time, evaluates the use of tape-stripping and proteomic analysis for the diagnosis and investigation of mycosis fungoides, a type of non-Hodgkin lymphoma that affects the skin.

The study found that tape stripping, a non-invasive method of collecting samples of the stratum corneum (the outermost layer of the skin), was effective in identifying important protein signatures of mycosis fungoides and identifying specific molecular pathways associated with the disease. Our team used a combination of mass spectrometry and bioinformatics analysis to identify and quantify proteins in the tape-stripped samples.

The results of the study showed that tape-stripped samples were suitable for lesion sampling, and that proteomic analysis of the samples provide valuable information on the underlying molecular mechanisms of the disease.

We suggest that tape stripping and proteomic analysis could be used as a non-invasive diagnostic and research tool for mycosis fungoides and other skin diseases, potentially leading to more personalized and effective treatments for patients.

The published article will be available for open access soon.